The Koegel Autism Center's primary research goals are increasing our understanding of autism spectrum disorders, the development and implementation of state-of-the-art pivotal response treatments, as well as the improvement of elementary and secondary education efforts for children with autism and other severe disabilities. The center's primary interests lie in research and training (both pre-service and in-service), focusing on family support and on the education of children with autism in community environments and classrooms with their typically developing peers. The center conducts research regarding the development of treatment delivery systems through families, schools, non-disabled peers, and others who provide support for children with autism in educational settings. The center is funded by a number of sources, including the state of California, federal research and training grants from the National Institute of Mental Health, the Department of Education, and through private donations.

The Center also provides a number of undergraduate, graduate, and paraprofessional training programs that have the goal of teaching "state-of-the-art" intervention techniques. Research is conducted to assess the effect these programs have on family life, on the improvement of the children's language and behavior, and on the level of increased community and school integration. 

A third major research focus consists of the development and implementation of non-aversive treatment interventions. These interventions are extremely beneficial for the treatment of severe behavioral problems such as self-injury and aggression. In the past, many painful, extremely aversive procedures were used with individuals with severe disabilities to decrease inappropriate behaviors. The center's multi-site research project has developed a number of non-aversive strategies for promoting generalization and maintenance of treatment gains. These strategies have also been shown to increase desired behaviors while simultaneously decreasing undesirable behaviors. Research projects resulting in significant gains for individuals utilize Pivotal Response Treatments (PRT®).